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REPORT Of the National Vaccine Establishment. To the Right Honourable Viscount Sidmoulh, National Vaccine. Establishment, Leicestester-square, Jprit22d, 1813. Mv Lo E Board of tlio National Vac- cine Establishment have the honour of informing your Lordship, that during the year 1812 the Surgeons appointed by their authority to the nine Stations in London, have vaccinated 4,521 per- sons, and have distributed 23,319 charges of Vac- cine Lyfiiph to the Public. The number vacci nated this year exceeds that of 1811 by 1,373, and the demand for Lymph has been ofren so great that it could not without difficulty be sup- plied. The Board had Jast year reason to think that nearly two-thirds of the children born in the Metropolis, were vaccinated by charitable Insti- tutions, or private Practitioners. There is now reason to believe that three-fourths of those born are submitted to that salutary operation. But" though the prejudices against the Sow Pock, which have been artfully encouraged by ignorant and interested men, appear gc,jerkily to decline in the Metropolis, as well as in (.,tier parts of these Dominions, yet it is with concern that the Board have noticed the increase of mortality from Small Pox in this City last year, to the number of 1,287. Previous to the discovery of Vaccination the average number of deaths from Small Pox, within the Bills of Mortality, was 2,000 and though in the last ten years 133,139 persons were added to the population of this great City, yet in 1811, by the benefit of Vaccination, the mortality was reduced to 751, The increase in the last year, we have reason to ascribe io the rash and incon- siderate manner n which great numbers are still inoculated for the Small Pox, and afterwards (equired to attend two or three times a week, at the place of Inoculation, and of promiscuous in- tercourse of the Patients at the same time with Society, is the great weallS by which this Disease is kept in existence, and its infection propagated to persons and places where it would not otherwise be seen. This is not only the opinion of this Board, faucded on observation, but it is a tact confirmed by communications to them Fruai 'he best auUiorUies, and by the most unprejudiced characters. The respectable College of Surgeons of Dublin allege that the practice of Liociiiatinn not only supplies acoiistanf source of infection, buttpre- vents the extinction of the disease, for even a short interval. The populous City of Norwich was never free from if till the discovery of Vaccination, but since that period it has experienced occasional remissions from its ravages. In I SOT, after its disappearance for some time, the disorder was brought into that City hy a Vagrant from London, who, before the [Magistrates were ap- prized of it, or, before the salutary advice given by the Faculty to provide a place where such, person might he secluded from intercourse with the inhabitants could be adopted, communicated the contagion. Of 1,200, who took 'he infection, 203 died. At that period, viz. 1807, the preju- dices against Vaccination had not subsided. But in 1812, when that City was threatened with a similar visitation, by the appearance of the Small Pox in the neighbourhood, the Magistrates the Faculty, and the Clergy concurred in recom- mending Vaccination. Between the 10th of Au- gust, and 22d of October following, 1316 persons were vaccinated. The result was, that though one gentleman, whose child the Faculty refused tc, iiijiociilate, procured matter of Small Pox, which he applied himself, and from this source seven persons took the infection, yet by means of this seasonable Vaccination not a life was lost. This result, so (iiiferent froin the events of 1807, cannot but. make an impression oil every mind open fo conviction when Vaccination was not performed 1,200 persons took the Small Pox, of which number 203 died when speedy recourse was had to Vaccmaciou there was not a victim to the disease. But. it is not at home only that lessons, so much to the credit of this new art, may be learned The Board have abundant communica- tions from every quarter of the world equally to its advantage. To detail all the evidence which they may have received as to its e'Rcacy, not only in preventing the Small Pox, but its power to suppress its ravages under the most unfavour- able and threatening circumstances, would extend this Report to an irriproper and an unusual length. They will content themselves with mentioning a few particulars, which they trust will recommend it to the favour and confidence of their country- men, and to the fostering care of Government. ()" tl)C-,botit;netit of I i)(i.a V;icriniitioti has I)ee!i hailed as the greatest blessing, and has been practised with the greatest success, and in the most extensive manner In the Islands of Ceylon and Bourbon it has been received in a manner no less favourable, and been practised with an efTect no less beneficial. In the Isle of Ceylon, since its first introduction, more than 200,000 persons have been vaccinated: 80,491 in theyar 1811 only, as appears by the subjoined table from Mr. Anderson, the Super- intendant General, to whom but one case of fai- lure, in preventing the Small Pox, (and the cir- cumstances of this case render it very doubtful) has occurred, in the great numbers which he has seen. At the Cape of Good Hope the Small Pox is dreaded as much as the Plague, and it has proved there little less destructive fo human life. Lord Caledon, the late Governor, established at Cape Town a Vaccine Institution, which was soon called into activity under his successor Sir J. Cradock. The colony consists of a population of 80 or DO,000 individuals, of which number it was supposed 15,000 were subject, to take the iu- fection of the Small Pox, which appeared there ou the 12th March 1812. Between that lime and the 4th July following 233 persons caughp. the disease, of which number 100 died. The remaining part of the inhabitants liable to tha disorder were preserved by an active Vaccitia- j tion, in which all the faculty in the place, as well as the regimental and garrison Surgeons, strenuously exerted themselves. From the various details with which the Board have been favoured, we think it our duty to select one instance, as tending to show iu a most pointed manner the power of the Vaccine Lymph to arrest the contagion of the Small Pox. Four hundred Negroes from Mosambique were on the 1st of March landed at Cape Town, one of whom, a woman, was on the 5th succeeding afflicted with the confluent Small Pox in its most virulent form. This female was at that time in. habiting a large room, in common with 200 more of her companions, not separated eiiher by "Maj- or night. On-the report of this case the whole of these victims of avarice and cupidity," as the surg-eon terms them, were immediately sub- jected to Vaccination, and on the following day removed to'a 'Sniall island (I'aiii-(Iell Island) at a little distance from the Town. A few days after this the woman fella sacrifice to the mostaggra- vated character of that dreadful disease. Of the aggregate number of Negroes, 78 individuals re- ceived the Vaccine disorder, and underwent the regular course of its action. Froll these subjects the remaining portion were vaccinated. "They remained on the Island 50 days, during which no further case of Small Pox made its appear- ance, although they had been exposed to the whole strength of the contagious atmosphere, nor is there a single instance wherein any of this large proportion of persons became subject to ille Small Pox." It. is added by the profes- sional gentleman who writes this account, that throughout the entire course of this «' arduous struggle" (the general Vaccination) not a single instance had come to his knowledge of the failure of Vaccination in protecting the individual from the Small Pox, whera the former was ascertained to have taken effect. (To be continued-)